Based on the intensive investigations on the catalytic cracking reactions for hydro-treated tail oil residue, a 5-lump reaction network and its kinetic model have been established. Based on experimental data obtained from catalytic dewaxing equipment, a computational program was written by Marquardt++ method and Matlab language; and activation energy, reaction rate constant and preexponential factors were calculated. It turns out that the model fits well with raw materials and reaction conditions change, and product distributions and their yields are predicted well under different conditions.